PROJECT

Lifestyle Interventions to Prevent or Delay the Onset of Polycystic Ovary Syndrome among Adolescent Girls: A Systematic Review and Meta-analysis

Nov 2025 - May 2026

Objectives:

To evaluate the effectiveness of lifestyle interventions in preventing or delaying the onset of PCOS among adolescent girls aged 10–19 years. To assess the impact of different intervention types (dietary, physical activity, behavioural or multi-component). To examine differences between general adolescents and those at risk of PCOS and evaluate changes in metabolic and reproductive risk markers.

Study Overview:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and is associated with metabolic disturbances, infertility risk, and long-term health complications. Evidence indicates that many cases originate or become clinically apparent during adolescence, a critical period for prevention. This systematic review aims to evaluate the effectiveness of lifestyle interventions in preventing or delaying the onset of PCOS among adolescent girls aged 10–19 years.

Study Approach:

A systematic review and meta-analysis will be conducted using a predefined protocol. The population includes adolescent girls aged 10–19 years, including both general populations and those at risk of PCOS. Eligible studies will be identified through comprehensive database searches and synthesised using meta-analytic techniques where appropriate.

Expected Public Health Impact:

The review will generate evidence on the preventive role of lifestyle interventions during adolescence. The findings may inform school health programmes, adolescent health strategies and clinical guidance for early PCOS risk reduction in India. Database searching and title-abstract screening has been completed and data extraction is currently ongoing.