PROJECT

Identification of Bovine Tuberculosis Specific Proteins by the Immuno Proteomic Approach

June 2025 - May 2026

Objectives:

Primary objective of the study is to identify the bovine tuberculosis specific protein by the immunoproteomic analysis of the culture filtrate proteome of M. tuberculosis of bovine origin.

Study Overview:

This is an in vitro and in vivo based laboratory study

Study Approach:

The current proposal aims to identify bovine tuberculosis-specific antigens by systematically characterizing the immune response to the culture filtrate proteome of bovine-origin Mycobacterium tuberculosis isolates obtained from previous studies conducted at ICMR-NIRT. This approach is expected to facilitate the discovery of immunodominant proteins that could serve as potential biomarkers for improved diagnosis and understanding of bovine tuberculosis.

Expected Public Health Impact:

The proposed approaches are expected to identify novel bovine tuberculosis-specific antigens associated with bovine-origin Mycobacterium tuberculosis isolates. Identification of these immunodominant antigens will provide valuable candidates for the development of more sensitive and specific blood-based diagnostic assays for bovine tuberculosis. Such improved diagnostic tools could facilitate early detection, enhance disease surveillance, and support effective control and prevention strategies for bovine tuberculosis.