PROJECT

Cost comparison of UniAMP sputum swab and Tongue swab UniAMP MTB for Tuberculosis in India

September 2025 - May 2026

Objectives:

To assess the cost implications of implementing the UniAMP test in TB diagnosis.

Study Overview:

This Health Technology Assessment (HTA) evaluates the diagnostic performance and cost implications of the UniAMP point-of-care molecular test using sputum and tongue swab samples compared with Truenat for detecting pulmonary TB among adults in India. Using a decision-tree model and micro-costing approach, the study estimates diagnostic accuracy, costs and cost-effectiveness from a health-system perspective to inform TB diagnostic strategies under the National TB Elimination Programme (NTEP).

Study Approach:

A decision-tree model was developed to compare UniAMP (sputum swab and tongue swab) with Truenat for diagnosing pulmonary TB among adults (>18 years) presenting with presumptive TB at public health facilities. The analysis was conducted from a health-system perspective, including direct diagnostic costs such as equipment, consumables, cartridges and human resource time. Diagnostic accuracy parameters (sensitivity and specificity) were obtained from published studies and ICMR validation reports using MGIT culture as the reference standard.

Expected Public Health Impact:

The study will provide evidence on the diagnostic performance and cost implications of the UniAMP point-of-care molecular test compared with Truenat for pulmonary TB diagnosis. The findings will inform decision-making on the potential use of UniAMP as a decentralized diagnostic option under the National TB Elimination Programme (NTEP). This may support early detection and improve access to rapid and affordable TB diagnosis in public health facilities.