PROJECT

An affordable and easy-to-use optical biosensor for mannosylated lipoarabinomannan Mtb LAM in urine for TB diagnosis

June 2025 - December 2026

Objectives:

Evaluation of plasmonic fiber optic absorbance biosensor (P-FAB) device using urine samples from suspected TB patients in comparison to M.tb cultures as gold standard

Study Overview:

This study will evaluate a urine-based P-FAB biosensor device for detecting tuberculosis in suspected patients. Its performance will be compared with standard Mycobacterium tuberculosis culture to assess its diagnostic accuracy.

Study Approach:

This is a cross-sectional validation study

Expected Public Health Impact:

This study will evaluate the effectiveness of a urine-based P-FAB assay for tuberculosis diagnosis, providing a non-invasive diagnostic approach. The findings may help improve the TB diagnostic care cascade and support better patient management and early detection.