PROJECT

Characterisation of Immune Responses in Tuberculosis Associated Chronic Obstructive Pulmonary Disease

January 2025 - December 2026

Objectives:

To characterize circulating immune biomarkers and TB antigen–specific innate and adaptive immune responses in TB-associated COPD (TOPD) and compare them with smoking-associated COPD (COPD-C) and healthy controls.

Study Overview:

This study aims to understand how the immune system changes in people who develop chronic lung disease (COPD) after recovering from pulmonary tuberculosis. It will compare immune responses in TB-associated COPD with those in smoking-related COPD and healthy individuals. The findings may help identify immune markers that explain why some TB patients develop long-term lung complications.

Study Approach:

This is a cross-sectional study designed to identify clinically relevant immune biomarkers that can distinguish TB-associated COPD (TOPD) from smoking-associated COPD (COPD-C).

Expected Public Health Impact:

This study will help to better understand the relationship between tuberculosis and COPD and the role of innate and adaptive immune responses in this association.