PROJECT

Assessment of Intestinal barrier integrity in Tuberculosis and its association with anti-TB drug levels

January 2026 - December 2027

Objectives:

To compare the intestinal barrier integrity and the biomarkers of intestinal barrier integrity of pulmonary tuberculosis patients with healthy controls. To correlate the intestinal barrier integrity with blood anti-TB drug levels in pulmonary tuberculosis patients

Study Overview:

Tuberculosis (TB) treatment requires long-term medication. Prolonged illness and the medicines used for treatment may affect the intestinal barrier, which plays an important role in the absorption of drugs from the intestine into the blood. A healthy and intact intestinal barrier plays an important role in the absorption of medicines and nutrients, which are important for patients with tuberculosis. The purpose of this study is to assess intestinal barrier integrity and to understand how it may influence the absorption of anti-tuberculosis medicines.

Study Approach:

This research study will be conducted among newly diagnosed pulmonary tuberculosis patients and healthy controls. Intestinal barrier integrity and blood levels of anti-tuberculosis drugs will be analysed using validated laboratory methods and advanced analytical techniques.

Expected Public Health Impact:

The study will help understand whether intestinal barrier dysfunction influences anti-TB drug absorption and treatment response. Findings may contribute to improved treatment monitoring strategies and support development of tools to optimize TB therapy and prevent drug resistance.