Stratifying low level isoniazid resistance using additional intermediate drug concentration.

Lakshmi, R.; Ranjani, R.; Syam Sundar, A.; Rahman, F.; Kumar, V.

International Journal of Mycobacteriology; 2014; 3; 152-154.

Abstract: Isoniazid (INH) susceptibility testing for 100 Mycobacterium tuberculosis performed by conventional minimum inhibitory concentration (MIC) method was stratified using additional drug concentrations. Introduction of additional drug concentrations did not greatly improve the discriminatory capacity, but can be used in specialized studies pertaining to cross resistance between structural analogues of INH.

Keywords: M. tuberculosis, Minimum inhibitory concentration, Isoniazid, Drug resistance




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