Effect of 1,25-dihydroxy vitamin D3 on toll-like receptor gene expression in neutrophils of pulmonary tuberculosis.

Harishankar, M.; Afsal, K.; Meenakshi, N.; Selvaraj, P.

Current Science; 2014; 107; 642-645.

Abstract: We studied the effect of 1,25-dihydroxy vitamin D3 [1,25(OH) 2 D 3 ] on toll-like receptor (TLR) gene expression in neutrophils cultured with Mycobacterium tuberculosis ( Mtb ) with or without 1,25(OH) 2 D3 in pulmonary tuberculosis patients and healthy controls. 1,25(OH) 2 D3 significantly increased the expression of TLR2, TLR9 and TIRAP genes compared to control cells in both the study groups ( P < 0.05). In healthy controls, a significantly upregulated expression of TIRAP was observed in Mtb infected cells cultured with 1,25(OH) 2 D3 compared to Mtb infected cells alone ( P < 0.05). In conclusion, 1,25(OH) 2 D3 upregulated the expression of TLR and TIRAP genes, which could lead to the activation of TLR signaling pathways and augment the innate immunity to tuberculosis.


Keywords: Gene expression; neutrophils; tuberculosis; toll-like receptors.


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