Combined drug medium with isoniazid and rifampicin for identification of multi-drug resistant Mycobacterium tuberculosis.

Nalini, S.; Lakshmi, R.; Devika, K.; Ravikumar, D.; Ranjani, R.

Indian Journal of Medical Microbiology; 2010; 28; 162-163.

Abstract: A low-cost method of detecting multi-drug resistant Mycobacterium tuberculosis (MDR-TB) with the possibility of quick adoption in a resource limited setting is urgently required. We conducted a study combining isoniazid and rifampicin in a single LJ medium, to detect MDR-TB strains. Combined and individual drug media showed 100% concordance for the detection of MDR-TB and susceptible strains by proportion method. Considering the results, combined isoniazid and rifampicin containing medium could be considered for use in settings where the sole detection of MDR-TB strains is justified.

Keywords: Mycobacterium tuberculosis ; MDR-TB; Isoniazid; Rifampicin, PST

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