Drug resistance in tuberculosis in India.

Paramasivan, C.N.; Venkataraman, P

Indian Journal of Medical Research; 2004; 120; 377-386.

Abstract: The current global concern in the treatment of tuberculosis (TB) is the emergence of resistance to the two most potent drugs viz ., isoniazid and rifampicin. The level of initial drug resistance is an epidemiological indicator to assess the success of the TB control programme. Though drug resistance in TB has frequently been reported from India, most of the available information is localized, sketchy or incomplete. A review of the few authentic reports indicates that there is no clear evidence of an increase in the prevalence of initial resistance over the years. However, a much higher prevalence of acquired resistance has been reported from several regions, though based on smaller numbers of patients. A strong TB control programme and continuous surveillance studies employing standardized methodology and rigorous quality control measures will serve as useful parameters in the evaluation of current treatment policies as well as the management of multidrug resistant (MDR) TB cases.

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