Response of patients with initially drug-resistant organisms to treatment with short-course chemotherapy.
Rema Mathew; Santha, T.; Parthasarathy, R.; Rajaram, K.; Paramasivan, C.N.; Janardhanam, B.; Somasundaram, P.R.; Prabhakar, R.
Indian Journal of Tuberculosis; 1993; 40; 119-123.
Summary: The study reports on the response of 763 patients with organisms initially resistant to Streptomycin, Isoniazid and Streptomycin plus Isoniazid, to treatment with short-course regimens containing Streptomycin with or without Rifampicin and oral regimens containing Rifampicin with or without Ethambutol. Resistance to Streptomycin alone did not influence the outcome. For resistance to Isoniazid, alone or in combination with Streptomycin, the response was significantly better when the regimens contained Rifampicin either daily for 2 or 3 months or intermittently for 6 months. The oral regimens studied were not effective in the presence of resistance to Rifampicin plus Isoniazid or Streptomycin plus Rifampicin plus Isoniazid, even when they contained Ethambutol. The implications of these findings for the National Tuberculosis Programme are discussed.
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