Anticonvulsant drugs and women with seizures.

Ramamurthi, B.; Manjula Datta; Kanthimathi David.

Journal of Obstetrics and Gynaecology; 1992; 42; 438-431.

The incidence of congenital anomalies in children born to mothers under anticonvulsant therapy has been studied, in 2536 women who gave birth to 3348 children. The follow-up period varied between 3 to 20 years. The mothers had received barbiturates, hydantoinates and carbamezapine in various combinations. The incidence of congenital anomalies noted was only 41, a figure not greater than the incidence of anomalies in the general population. A plea is made that anticonvulsant therapy should not be discontinued during pregnancy in women with seizures.

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