Hydrogen peroxide release by OKIa1 (anti-DR-monoclonal antibody) resistant alveolar macrophages in tuberculosis.

Selvaraj, P.; Rajiswami, S.; Vijayan, V.K.; Prabhakar, R.; Narayanan, P.R.

Indian Journal of Chest Diseases and Allied Sciences; 1989; 31; 141-149.

Phorbol myristate acetate (PMA) triggered hydrogen peroxide (H 2 O 2 ) release from alveolar macrophages and corresponding blood monocytes were studied as a whole, in active tuberculosis, inactive tuberculosis (treated), non-tuberculous lung disease patients and normal individuals. Irrespective of the study subjects, the alveolar macrophages produced less H 2 O 2 than the corresponding blood monocytes. The alveolar macrophages that were resistant to OKIa1 (Anti-DR monoclonal antibody and complement treatment) produced an increased level of H 2 O 2 than the control ascites and complement treated alveolar macrophages. Moreover, such increase in H 2 O 2 release was not seen with peripheral blood monocytes; more than 90% monocytes were OKIa1 resistant population. These OKIa1 resistant alveolar macrophages are probably important in their metabolic, microbicidal and the immunological functions.


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