Intraspecies differentiation of strains of Mycobacterium tuberculosis obtained from Czechoslovakian, Mongolian and South Indian patients.
Venkataraman, P.; Paramasivan, C.N.; Ilampuranam, K.J.; Prabhakar, R.
Indian Journal of Medical Research; 1988; 88; 211-216.
Twenty nine strains of M. tuberculosis from Czechoslovakia, 46 from Mongolia and 50 from South India were tested for virulence in the guinea-pig, sensitivity to thiophen-2-carboxylic acid hydrazide (TCH) and phage type. Most of the Czechoslovakian and Mongolian strain (93 and 80% respectively) were highly virulent in the guinea-pig while only 36 per cent of the South Indian strains showed high virulence. Similarly very high proportion of Czechoslovakian (97%) and Mongolian strains (85%) were resistant to TCH as against only 22 per cent of South Indian strains. The phage type I was observed in none of the Czechoslovakian strains, 4 per cent of Mongolian strains and in 68 per cent of South Indian strains. Thus, the Czechoslovakian and Mongolian strains, in general, resembled the classical M. tuberculosis , while the South Indian strains were generally of low virulence, susceptible to TCH and of phage type I.
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