Immunological investigations in tuberculous ascites.

Rajiswami, S; Acharyulu, G.S.; Rani Balasubramanian; Narayanan, P.R.; Prabhakar, R.

Indian Journal of Tuberculosis; 1988; 35; 3-7.

Cell mediated immunity was assessed in seven patients with bacteriologically and/or histologically confirmed tuberculous ascites. Eight non-tuberculous ascites patents were included as controls. Anti-PPD antibody levels were also estimated by ELISA. Macrophages from tuberculous ascetic fluid showed increased production of H 2 O 2 when compared with ascetic fluid macrophages from controls. Proliferation response of lymphocytes to PPD antigen was greater in ascetic fluid than in peripheral blood in tuberculous patients, while the responses were reversed in control patients. Tuberculous ascetic fluid had higher levels of anti-PPD antibodies than ascetic fluid from controls, though their levels in peripheral blood were similar in the two groups. It is concluded that the results provide support to the concept of immunological localization.


Back to List of publications / Home