Virulence in the guinea-pig and susceptibility to hydrogen peroxide of isoniazid-sensitive tubercle bacilli from South Indian patients.
Narayanan Nair, C.; Mackay-Scollay, E.M.; Ramachandran, K.; Selkon, J.B.; Tripathy, S.P.; Mitchison, D.A.; Dickinson, Jean M.
Tubercle; 1964; 45; 345-353.
Tests for virulence in the guinea pig and for susceptibility to the bactericidal activity of hydrogen peroxide were done on cultures of isoniazid-sensitive tubercle bacilli obtained from 220 South Indian patients with pulmonary tuberculosis before the start of anti-tuberculosis chemo-therapy.
An association was found between the virulence of the cultures and the proportion of their organisms surviving exposure to 0.02% peroxide; 10% or more organisms survived in 11% of 152 cultures of low virulence and in 57% of 68 cultures of high virulence. There was some suggestion that the cultures could be divided into two groups, the larger, containing about 74% of the cultures, having low virulence and high peroxide susceptibility and the smaller having high virulence and low peroxide susceptibility.
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