The results of treatment with streptomycin plus pyrazinamide in patients with active pulmonary tuberculosis despite prolonged treatment with isoniazid plus PAS.
Velu, S.; Andrews, R.H.; Devadatta, S.; Wallace Fox; Ramakrishnan, C.V.; Subbaiah, T.V.
Indian Journal of Tuberculosis; 1960; 7; 85-94.
Twenty patients with chronic pulmonary tuberculosis and organisms sensitive to streptomycin were treated with daily streptomycin plus pyrazinamide, the majority attending a clinic daily for the therapy; all had previously been treated with isoniazid plus PAS.
Treatment was stopped in 7 patients after 8 to 10 months because the disease was still active.
Of the 20 patients 13 completed a year's treatment, and 10 attained bacteriological quiescence.
Sputum conversion was very rapid in the patients who attained bacteriological quiescence.
A clear-cut "fall and rise" phenomenon associated with a high level of streptomycin resistance was present in the patients whose response was unsatisfactory.
Toxicity was not a problem with either drug.
It is possible in India, given especially favourable clinic facilities, to administer long-term daily streptomycin and pyrazinamide under ambulatory conditions.
Back to List of publications / Home |