| Regulatory role of Cdx-2 and Taq I polymorphism of Vitamin D Receptor gene on chemokine expression in pulmonary tuberculosis.
Harishankar, M .; Selvaraj, P.
Human Immunology; 2016; 77; 498-505
Abstract: Vitamin D receptor (VDR) gene variants have been shown to be regulating the immune response in tuberculosis. We studied the regulatory role of VDR promoter Cdx-2 and 30UTR Taq I gene variants on chemokine levels from culture filtrate antigen (CFA) stimulated with or without 1,25(OH)2 D3 treated peripheral blood mononuclear cells of 50 pulmonary tuberculosis patients (PTB) and 51 normal healthy controls (HCs). In CFA with 1,25(OH)2 D3 treated cultures, the MIP-1 a , MIP-1 b , RANTES levels were significantly decreased in Cdx-2 AA genotype compared to GG genotype, while a significantly increased MIG level was observed in Cdx-2 AA genotype (p < 0.05). In Taq I polymorphism, tt genotype significantly decreased MIP-1 b and RANTES levels compared to TT genotype. Moreover, a significantly increased level of IP-10 and MIG was observed in Taq I tt genotype compared with TT genotype (p < 0.05). The results suggests that the 1,25(OH)2 D3 may alter the chemokine response through the VDR polymorphic variants during infection.
Keywords: Vitamin D receptor; Chemokine; Gene polymorphism; Culture filtrate antigen and tuberculosis
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