Modulation of CD4 + and CD8 + T cell function by Interleukin 19 and Interleukin 24 during filarial infections.

Anuradha, R .; Munisankar, .S .; Dolla, C .K.; Kumaran, P .; Nutman, T.B .; Babu, S .

Journal of Infectious Diseases; 2016; 213; 811-815

Abstract : Interleukin 19 (IL-19) and interleukin 24 (IL-24) are cytokines that are highly expressed in filarial infections. To study the role of IL-19 and IL-24 in regulating T-cell responses, we examined the frequency of T-helper type 1 (Th1)/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated with filarial antigen following IL-19 or IL-24 neutralization. IL-19 or IL-24 neutralization resulted in significantly enhanced frequencies of Th1/Tc1 and/or Th17/ Tc17 cells and significantly reduced frequencies of Th2/Tc2, Tr1, and/or Th9/Tc9 cells. Thus, we demonstrate that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections.

Keywords: Filarial infections; T cells; cytokines; IL-19; IL-24; IL-10.

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