Mave, V.; Chandanwale, A.; Kinikar, A.; Khadse, S.; Kaga, A.; Gupte, N.; Suryavanshi, N.; Nimkar, S.; Koli, H.; Khwaja, S.; Bharadwaj, R.; Joshi, S.; Horng, H.; Benet, L.Z.; Ramachandran, G.; Dooley, K.E.; Gupta, A.; Gandhi, M.

International Journal of Tuberculosis and Lung Disease; 2016; 20; 844-847.

Summary: Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a ‘proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.

Keywords: Tuberculosis; paediatric TB; therapeutic drug monitoring; isoniazid drug concentrations; hair assays

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