SLCO1B1 gene polymorphisms do not influence plasma rifampicin concentrations in a south Indian population.

Ramesh, K.; Hemanth Kumar, A.K.; Kannan, T.; Vijayalakshmi, R.; Sudha, V.; Manohar Nesakumar, S.; Bharathiraja, T.; Lavanya, J.; Swaminathan, S.; Ramachandran, G.

International Journal of Tuberculosis and Lung Disease; 2016; 20; 1231-1235.    

Summary: Objective: To determine the effect of SLCO1B1 gene polymorphisms ( rs 11045819, rs 4149032 and rs 4149033) on rifampicin (RMP) concentrations in adult tuberculosis (TB) patients from south India .

Methods: We genotyped adult TB patients for three SLCO1B1 gene polymorphisms— rs 11045819, rs 4149032 and rs 4149033—and compared 2-h post-dosing RMP concentrations of the different genotypes for each of the polymorphisms. Plasma RMP was determined using high-performance liquid chromatography. Genotyping was performed using direct sequencing.

Results: Among the 256 study patients, minor allele frequencies were respectively 0.01 (A), 0.46 (C) and 0.07 (A) for rs 11045819, rs 4149032 and rs 4149033 polymorphisms; genotype distributions followed Hardy- Weinberg equilibrium. RMP concentrations did not significantly differ between the different genotypes of the three polymorphisms.

Conclusion: This is the first study to show that rs 11045819, rs 4149032 and rs 4149033 polymorphisms in the SLCO1B1 gene did not influence RMP concentrations in Indian patients.

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