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LIST OF ONGOING STUDIES AS ON 10th FEBRUARY, 2021

Title of the study
 
Name of the Principal Investigator
     

Pharmacokinetic drug-drug interactions between first line anti-TB and anti-diabetic drugs

  Dr. A.K. Hemanth Kumar (hemanthkumarak@nirt.res.in)

Pharmacokinetics of second-line anti-TB drugs in children and adolescents with MDR TB

  Dr. A.K. Hemanth Kumar (hemanthkumarak@nirt.res.in)

Bioavailability of fixed dose combination of first line anti-TB drugs in patients with pulmonary tuberculosis

  Dr. A.K. Hemanth Kumar (hemanthkumarak@nirt.res.in)

Molecular cloning and characterization of full length infectious Transmitted/Founder HIV-1 viruses

 

Dr. Luke E. Hanna
(hanna@nirt.res.in)

Identification of broadly neutralizing antibodies against HIV

  Dr. Luke E. Hanna
(hanna@nirt.res.in)

Inflammation and aging in HIV-infected individuals on long term antiretroviral therapy

  Dr. Luke E. Hanna
(hanna@nirt.res.in)

Identification of biomarkers that can predict progression from Latent Tuberculosis Infection to active TB disease

  Dr. Luke E. Hanna
(hanna@nirt.res.in)

National HIV Cohort Program Cohorts of HIV Resistance and Progression in Indian Children and Adults (CoHRPICA)

  Dr. Luke E. Hanna
(hanna@nirt.res.in)

Impact of malnutrition on immune responses to tuberculosis in Indian children

 

Dr. Aishwarya Venkataraman
(aishwarya.v@nirt.res.in)

Development and validation of a diagnostic kit for early detection of Human Papilloma Virus (HPV) infection in cervical cancer

 

Dr. N. Sudhakar
(sudhakar@nirt.res.in)

Latent  class analysis of health related quality of life of TB patients during & post treatment in a Longitudinal Design

 

Dr. M. Vasantha
(vasantha_m@nirt.res.in)

Development of a Database of Clinical Study X-rays at NIRT, Chennai 

 

Dr. C. Ponnuraja
cponnuraja@nirt.res.in)

HTA for implementation of cell counters for referral of suspected dengue cases at PHC settings

 

Dr. M. Muniyandi
(muniyandi.m@nirt.res.in)

The Economic evaluation of standardised treatment regimens of anti-TB drugs for patients with MDR-TB (STREAM stage-II trial)

  Dr. M. Muniyandi
(muniyandi.m@nirt.res.in)

Social network analysis as a tool to improve active case finding at community level in Chennai

 

Dr. N. Karikalan
(karikalan.n@nirt.res.in)

Measuring the socio-economic risk-benefits & health related quality of life changes associated with TB disease disclosure

  Dr. N. Karikalan
(karikalan.n@nirt.res.in)

Early bactericidal activity of anti-tuberculosis drugs

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

Protecting and improving public health globally: Building laboratory, surveillance and workforce capacity to detect, respond to, and prevent drug resistant tuberculosis in India

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

Identification of the latent tuberculosis specific marker by the immunoproteomic analysis of the cell wall and membrane proteins of M. tuberculosis.

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

Accurate, Rapid, Robust and Economical diagnostic technologies for Tuberculosis: ARREST-TB

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

Crohn's disease in India: A multicenter study from a country where intestinal tuberculosis as well as Johne’s disease is endemic

  Dr.P.Kannan
(kannanp@nirt.res.in)

Studies on epigenome wide alterations in alveolar macrophages during M. tuberculosis infections in guinea pig pulmonary tuberculosis model

  Dr.P.Kannan
(kannanp@nirt.res.in)

Whole Genome Sequencing and Transcriptome analysis of M. tuberculosis clinical isolates from Bovine and Human Origin

  Dr.P.Kannan
(kannanp@nirt.res.in)

Identification of Mycobacterium tuberculosis complex (MTBC) organisms in the lymph node samples of slaughtered cattle in Chennai

  Dr.P.Kannan
(kannanp@nirt.res.in)

Dereplication guided bio-prospecting of cyclic lipopeptides from marine Bacillus sp. for inhibition of M. tuberculosis

  DR. P.Kannan
(kannanp@nirt.res.in)
Mentor for the project ;
Dr Sagarika Devi- PI for the project

Systems biology and immunology of the effect of tuberculosis chemoprophylaxis in HIV infection

  Dr. Syed Hissar
(syed.hissar@nirt.res.in)
and
Dr. Pavan Kumar
(pavankumarn@nirt.res.in)

An open label, three arm, pragmatic, randomized controlled pilot study to determine the protective effect of Kabha sura kudineer (KSK)/ Nilavembu kudineer (NVK) in preventing COVID19 symptoms compared to standard Vitamin C-Zinc supplementation and to examine immune responses among healthcare workers.

  Dr. Pavan Kumar
(pavankumarn@nirt.res.in)
and
Dr. Subash Babu
(sbabu@nirt.res.in)

Identification of tuberculosis specific biomarkers in children by the Proteomic analysis of urine.

  Dr.D.Anbarasu
(harianbu@nirt.res.in)
and
Dr. Syed Hissar
(syed.hissar@nirt.res.in)

Molecular Analysis of monocyte subsets in humans infected with Mycobacterium tuberculosis

  Dr.Ramalingam B
(ramalingam.b@nirt.res.in)

Attenuated mycobacteria based vaccine against tuberculosis with a novel strategy for T cell priming

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

CRISPR mediated platform for diagnosis and rapid detection of drug resistance pattern in M. tuberculosis.

  Dr.K.R. Uma Devi
(umadevi.r@nirt.res.in)

Functional characterization of oxidoreductases of M. tuberculosis

  Dr.P.Kannan
(kannanp@nirt.res.in)

Study on Mutations Associated with Pyrazinamide Resistance in M. tuberculosis

  Dr.P.Kannan
(kannanp@nirt.res.in)

  A cross sectional study of the systems immunology and viral diversity of SARS-CoV2 infection, COVID-19 disease and Multisystem Inflammatory Syndrome in children

 

Dr. Pavan Kumar
(pavankumarn@nirt.res.in)
and
Dr. Subash Babu
(sbabu@nirt.res.in)

Characterization and Durability of COVID-19 vaccine induced immune responses in healthcare/frontline workers

  Dr. Pavan Kumar
(pavankumarn@nirt.res.in)
and
Dr. Banu Rekha
(banurekha@nirt.res.in)

Humoral and cellular immune response among recovered COVID-19 patients: A cross-sectional study, Tiruvallur district, Chennai Corporation, Tamil Nadu, India, 2020

  Dr. Pavan Kumar (Co PI)
(pavankumarn@nirt.res.in)

Role of neutralizing antibodies and inflammatory biomarkers in children with Paediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS)

  Dr. Pavan Kumar (Co PI)
(pavankumarn@nirt.res.in)

Regional Prospective Observational Research in Tuberculosis (RePORT) - Phase 2

  Dr. Pavan Kumar (Co PI)
(pavankumarn@nirt.res.in)

CYP2R1 gene polymorphisms in pulmonary tuberculosis   

  Dr. Ramalingam B
(ramalingam.b@nirt.res.in) &
Dr. Harishanker

Immunomodulation of Autophagy by Vitamin D3 in macrophages Infected with Mycobacterium tuberculosis

  Dr. Ramalingam B
(ramalingam.b@nirt.res.in)

Molecular and immune profiling in adults affected with COVID-19 disease

  Dr. N.Sudhakar
     

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